Blar i forfatter "Keski-Rahkonen, Pekka"

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    • Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition 

      Wedekind, Roland; Rothwell, Joseph A.; Viallon, Vivian; Keski-Rahkonen, Pekka; Schmidt, Julie A.; Chajes, Veronique; Katzke, Vna; Johnson, Theron; Santucci de Magistris, Maria; Krogh, Vittorio; Amiano, Pilar; Sacerdote, Carlotta; Redondo-Sánchez, Daniel; Huerta, José María; Tjønneland, Anne; Pokharel, Pratik; Jakszyn, Paula; Tumino, Rosario; Ardanaz, Eva; Sandanger, Torkjel M; Winkvist, Anna; Hultdin, Johan; Schulze, Matthias B.; Weiderpass, Elisabete; Gunter, Marc J.; Huybrechts, Inge; Scalbert, Augustin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-08)
      Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. <p><p>Methods: Circulating ACs were measured in blood by targeted (15 ACs) and ...

    • Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study 

      Ana-Lucia, Mayén; Aglago, Elom K.; Knaze, Viktoria; Cordova, Reynalda; Schalkwijk, Casper G.; Wagner, Karl-Heinz; Aleksandrova, Krasimira; Fedirko, Veronika; Keski-Rahkonen, Pekka; Leitzmann, Michael F.; Katzke, Verena; Srour, Bernard; Schulze, Matthias B.; Masala, Giovanna; Krogh, Vittorio; Panico, Salvatore; Tumino, Rosario; Bueno-de-Mesquita, Bas; Brustad, Magritt; Agudo, Antonio; López, María Dolores Chirlaque; Amiano, Pilar; Ohlsson, Bodil; Ramne, Stina; Aune, Dagfinn; Weiderpass, Elisabete; Jenab, Mazda; Freisling, Heinz (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-25)
      Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer ...

    • Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: a Prospective Study and Meta-Analysis 

      Mori, Nagisa; Keski-Rahkonen, Pekka; Gicquiau, Audrey; Rinaldi, Sabina; Dimou, Niki; Harlid, Sophia; Harbs, Justin; Van Guelpen, Bethany; Aune, Dagfinn; Cross, Amanda J.; Tsilidis, Konstantinos K.; Severi, Gianluca; Kvaskoff, Marina; Fournier, Agnès; Kaaks, Rudolf; Fortner, Renée Turzanski; Schulze, Matthias B.; Jakszyn, Paula; Sánchez, Maria-José; Colorado-Yohar, Sandra M.; Ardanaz, Eva; Travis, Ruth; Watts, Eleanor L.; Masala, Giovanna; Krogh, Vittorio; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Buenode-Mesquita, bas; Gram, Inger Torhild; Waaseth, Marit; Gunter, Marc J.; Murphy, Neil (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)
      Background - Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results.<p> <p>Methods - We investigated the associations between circulating concentrations ...

    • A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood 

      Wedekind, Roland; Kiss, Agneta; Keski-Rahkonen, Pekka; Viallon, Vivian; Rothwell, Joseph A; Cross, Amanda J.; Rostgaard-Hansen, Agnetha Linn; Sandanger, Torkjel M; Jakszyn, Paula; Schmidt, Julie A; Pala, Valeria; Vermeulen, Roel; Schulze, Matthias B; Kühn, Tilman; Johnson, Theron; Trichopoulou, Antonia; Peppa, Eleni; La Vechia, Carlo; Masala, Giovanna; Tumino, Rosario; Sacerdote, Carlotta; Wittenbecher, Clemens; de Magistris, Maria Santucci; Dahm, Christina C; Severi, Gianluca; Romana Mancini, Francesca; Vainio, Elisabete Weiderpass; Gunter, Marc J.R.; Huybrechts, Inge; Scalbert, Augustin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-03)
      <p>Background - Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited. <p>Objectives - ...

    • A new pipeline for the normalization and pooling of metabolomics data 

      Viallon, Vivian; His, Mathilde; Rinaldi, Sabina; Breeur, Marie; Gicquiau, Audrey; Hémon, Bertrand; Overvad, Kim; Tjønneland, Anne; Rostgaard-Hansen, Agnetha Linn; Rothwell, Joseph A.; Lecuyer, Lucie; Severi, Gianluca; Kaaks, Rudolf; Johnson, Theron; Schulze, Matthias B.; Palli, Domenico; Agnoli, Claudia; Panico, Salvatore; Tumino, Rosaria; Ricceri, Fulvio; Monique Verschuren, Verschuren; Engelfriet, Peter; Onland-Moret, Charlotte; Vermeulen, Roel; Nøst, Therese Haugdahl; Urbarova, Ilona; Zamora-Ros, Raul; Rodríguez-Barranco, Miguel; Amiano, Pilar; Huerta, José María; Ardanaz, Eva; Melander, Olle; Ottoson, Filip; Vidman, Linda; Rentoft, Matilda; Schmidt, Julie A.; Travis, Ruth C.; Weiderpass, Elisabete; Johansson, Mattias; Dossus, Laure; Jenab, Mazda; Gunter, Marc; Bermejo, Justo Lorenzo; Scherer, Dominique; Salek, Reza M.; Keski-Rahkonen, Pekka; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-17)

    • Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality 

      Loftfield, Erikka; Stepien, Magdalena; Viallon, Vivian; Trijsburg, Laura; Rothwell, Joseph A.; Robinot, Nivonirina; Biessy, Carine; Bergdahl, Ingvar A.; Bodén, Stina; Schulze, Matthias B.; Bergman, Manuela; Weiderpass, Elisabete; Schmidt, Julie A.; Zamora-Ros, Raúl; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Sonestedt, Emily; Ohlsson, Bodil; Katzke, Verena; Kaaks, Rudolf; Ricceri, Fulvio; Tjønneland, Anne; Dahm, Christina C.; Sánchez, Maria-Jose; Trichopoulou, Antonia; Tumino, Rosario; Chirlaque, María-Dolores; Masala, Giovanna; Ardanaz, Eva; Vermeulen, Roel; Brennan, P; Albanes, Demetrius; Weinstein, Stephanie J.; Scalbert, Augustin; Freedman, Neal D.; Gunter, Marc; Jenab, Mazda; Sinha, Rashmi; Keski-Rahkonen, Pekka; Ferrari, Pietro (Preprint; Manuskript, 2021-05-19)
      Background - Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed because of measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk.<p> <p>Methods - Untargeted metabolomics was used to identify metabolites correlated with ...

    • Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition 

      Breeur, Marie; Ferrari, Pietro; Dossus, Laure; Jenab, Mazda; Johansson, Mattias; Rinaldi, Sabina; Travis, Ruth C.; His, Mathilde; Key, Tim J.; Schmidt, Julie A.; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Rothwell, Joseph A.; Laouali, Nasser; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Eichelmann, Fabian; Palli, Domenico; Grioni, Sara; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Olsen, Karina Standahl; Sandanger, Torkjel M; Nøst, Therese Haugdahl; Quirós, J. Ramón; Bonet, Catalina; Barranco, Miguel Rodríguez; Chirlaque, María-Dolores; Ardanaz, Eva; Sandsveden, Malte; Manjer, Jonas; Vidman, Linda; Rentoft, Matilda; Muller, David; Tsilidis, Kostas; Heath, Alicia K.; Keun, Hector; Adamski, Jerzy; Keski-Rahkonen, Pekka; Scalbert, Augustin; Gunter, Marc J.; Viallon, Vivian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-19)
      Background - Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.<p> <p>Methods - We analysed targeted metabolomics ...